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GSK-LSD1 dihydrochloride
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
Catalog No. T2315Cas No. 2102933-95-7
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Purity:100%
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GSK-LSD1 dihydrochloride
Catalog No. T2315Alias GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)Cas No. 2102933-95-7
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 2 mg | $48 | In Stock | |
| 5 mg | $65 | In Stock | |
| 10 mg | $105 | In Stock | |
| 25 mg | $221 | In Stock | |
| 50 mg | $335 | In Stock | |
| 100 mg | $549 | In Stock | |
| 500 mg | $1,170 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $65 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B). |
| Targets&IC50 | LSD1:16 nM |
| In vitro | GSK-LSD1 induces gene expression changes in cancer cell lines with average EC50 of < 5 nM and inhibits cancer cell line growth with average EC50 of < 5 nM. [1] |
| Alias | GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride) |
| Molecular Weight | 289.24 |
| Formula | C14H22Cl2N2 |
| Cas No. | 2102933-95-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 4.23 mg/mL (14.63 mM), Sonication is recommended.  H2O: 10 mg/mL (34.57 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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